CoQ10

I'm buying tome CoQ10.

While trawling the internet for more information on antioxidants, I found a useful summary which provided collection of studies on the effects of anti oxidants on sperm. Most interesting of this was this table, which provides an overview of all the studies, the anti-oxidants, and the results.

This study immediately caught my eye;

"RESULTS:

Mean sperm concentration, sperm progressive motility, and sperm with normal morphology improved significantly after 12-month CoQ(10) therapy by 113.7, 104.8, and 78.9%, respectively (all Ps < 0.05). The overall pregnancy rate was 34.1% within a mean of 8.4 ± 4.7 months.

CONCLUSIONS:

CoQ(10) supplementation improves semen quality with beneficial effect on pregnancy rate."

WOW! CoQ10 can improve sperm morphology by nearly 80%? 34% of participants had a spontaneous pregnancy during the study?! These are incredible figures!

This study was apparently a year long and involved 287 people taking 300mg of CoQ10 twice a day, so this isn't an overnight cure, but its a solid study and a promising start.

I've no idea if my poor sperm morphology is caused by oxidative stress or not, but even if its not, some CoQ10 apparently wont hurt my overall health, all of the CoQ10 studies appeared to have some sort of positive impact on sperm, with the higher doses having the greatest impact, so I'm heading over to Amazon now to do some shopping.

Lycopene (the tomato antioxidant)

I'm going to eat a lot more Tomatoes.

So, at the moment Antioxidants appears to be the way forward for improving Sperm morphology. And it turns out, there are loads of different types of Antioxidants.

In conducting my research I've come across another promising antioxidant called Lycopene. Lycopene is commonly found in tomatoes and other red vegetables. Something that my diet currently lacks.

There are a few promising articles about Lycopene and the effects on sperm (here, here, and here), the key headline appears to be 'New 'tomato pill' could SUPERCHARGE sperm by 70 per cent'

There is one old study here which suggests 4mg of Lycopene a day for 3 months had this result;

"Twenty patients (66%) showed an improvement in sperm concentration, sixteen (53%) had improved motility and fourteen (46%) showed improvement in sperm morphology."

There are clinical trials underway right now to prove whether 7mg can lead to further improvements, the supplement being tested has been developed by the university of Cambridge and can be found here.

While the previous studies appear promising, I'm reluctant to shell out cash for a somewhat unproven supplement, instead I've researched how many tomatoes I'll need to eat to get a daily dose of Lycopene.

This website suggests a simple tin of tomato soup will give me a whopping 13mg of Lycopene! so I'm going to adjust my diet accordingly to try and consume at least a tin of tomato soup a day.

UPDATE: This article reports on the effects a tin of tomato soup has on Lycopene levels in the testies (the antioxidant was detected but they didn't do any analysis into the impact on sperm).

What causes Teratozoospermia?

I've obviously been doing a lot of research into this recently, while I'm now convinced there appears to be a link between a lack of antioxidants and Teratozoospermia (see previous post), it doesn't explain everything away.

I know people who are a lot older than me, people who drink excessively, smoke, don't exercise and are generally unhealthy who have all managed to have kids.

It doesn't make sense, people have been having kids since the dawn of time without requiring huge amount of antioxidants, there must be more to it, so i did some more digging and here's what i found;

1. Nobody really knows what causes it

That's it!

Hodgkin's disease, coeliac disease, Crohn's disease, smoking, Varicocele, drugs, STD's, poor diet, pesticides, infections, excessive heat, diabetes, age, chemotherapy, excessive trauma, pollution, lifestyle.

All of these things could contribute to poor sperm morphology and lead to Teratozoospermia. But this is largely theoretical or based on limited evidence. And none of them truly impact me.

The only things i can think of which may apply to me could be Alcohol and genetics;

Alcohol; Yes, it appears as though Alcohol can really mess things up;

-  Alcohol can have profound deleterious effects at all levels of the male reproductive system.

- 'It causes impaired testosterone production, enormous testicular oxidative stress and testicular atrophy.'

ENORMOUS Oxidative stress! Time and time again it appears as a cause of poor sperm morphology, however I don't think i drink enough Alcohol to cause catastrophic damage to my sperm production, i probably only drink about 7 beers a week on average (but that's usually in one evening). That might cause some damage, but wouldn't be enough to render me totally infertile surely?

There's another study about the link between Oxidative Stress and Sperm which included some interesting figures about alcohol (see below) - people who had consumed alcohol in the last 3 months had a significantly lower sperm count, but they actually had slightly higher motility and concentration;

There are a lot more factors in play here which I'm breezing over, but essentially I'm just going to cut back on Alcohol. No more than 2 beers in any one evening should be fine, I'm not going to cut it out completely (that would be just too depressing!)

Genetics; A few websites touch upon this. They essentially suggest that the factory which produces the sperm is defective due to my genetics. Therefore the factory produces defective sperm with fragmented DNA. If this is the case then there is truly nothing that can be done for me, its simply the way I've been built, i cant change that any more than i can change the colour of my eyes... This study talks a little bit more about missing DNA sequences which could cause sperm to be defective, but it doesn't really mean much to me.

Perhaps my Dad has Teratozoospermia and its been passed on to me & amplified? Who knows (I'm hoping its not that).

Antioxidants; Teratozoospermia cure?

The doctor suggested increasing my intake of antioxidants may help improve my sperm. I didn't believe him at first, how can a simple cup of green tea make me fertile? It seemed like a stretch.

So i started the same place everyone does, Google.

Turns out 'oxidative stress' appears to be a major cause of infertility among men. So i started reading up about it;

"Like an apple turns brown when exposed to air, our cells can “rust” when we breathe due to oxidative stress, a process caused by free radicals. Free radicals are unstable molecules that damage or “oxidize” cells throughout the body in a process called oxidative stress."

Basically something as essential as breathing appears to cause free radicals, which can then go on to cause oxidative stress to sperm production, who knew?!

Free radicals can also be caused by alcohol, smoking, air pollution, or eating processed foods among other things... If you don't consume enough anti-oxidants, these free radicals can build up over time and apparently cause some real damage.

Now, I've never smoked, but I'm not exactly a fan of my fruits, and I've been known to drink a lot of beer and eat a lot of crap over the years. Perhaps its all finally caught up with me? Although I feel I've always been moderately healthy (If sperm morphology was determined by health alone, I'd expect my morphology to be in the 60% - 65% range), perhaps I've neglected anti-oxidants without even realising?

This study is particularly interesting, if I've understood it correctly, this graph essentially compares oxidant levels (LP, the left bar) and antioxidant levels (SOD, the right bar) in the testies of Teratozoospermic men;

You can see in Teratozoospermic men, the oxidant levels are almost off the charts.

There are a few more studies that support the theory, including this one which concluded ROS (Oxidative Stress) was much higher in Teratozoospermic men;

"RESULTS Sperm morphology was significantly poor in the Teratozoospermic Group compared with the 3 Donor Groups (P < 0.05). Significantly higher levels of ROS (RLU/sec/10⁶ sperm) were seen in the Teratozoospermic group (145.4 (41.5; 555.4) compared to the Donor Groups"

The below table compares the figures, in Teratozoospermic men Oxidative stress was 2.5 times higher than the 'proven donors' group;

So there appears to be a scientific consensus that there is a strong link between Oxidative Stress and poor sperm morphology. It is also accepted that antioxidants can help reduce oxidative stress.

Since 'Teratozoospermia' is essentially the term used to categorise men with seriously low morphology levels (0-4% according to the world Health Organisation), I'm led to believe that an enormous and ongoing dose of various antioxidants will improve my sperm morphology, and potentially move me out of the 'Teratozoospermia' bracket.

So the next step is to research antioxidants!

Day 0 - The test results

So today, after 18 months of trying to conceive, I picked up the results of my sperm test.

They're not great;

0% Normal morphology. Zero. The doctor said he's only ever seen one other case like it.

Diagnosis; Severe Teratozoospermia, technically I'm totally infertile.

The doctor informs me Teratozoospermia (aka Teratospermia) is a condition whereby the sperm are simply unable to penetrate the egg due to their shape. In my case the heads are either too big, too small, too long or too short, and the egg just wont allow it. Theres a video on this website which better explains things, anything below 4% morphology and you are classed as having Teratozoospermia.

As things currently stand, 0% morphology suggests i have literally zero chance of getting my wife pregnant, and this thought genuinely saddens me to my very core.

But I've decided I'm not going to sit here and cry about it, I'm going to research the hell out of this condition and I'm going to try and fix it.

I've searched around the internet and cant find much about Teratozoospermia, there're a few websites that provide more information on the condition, but not much support out there from the male perspective (as far as i can see so far anyway). So i figure I'd start a blog to detail my journey. If i happen to stumble across a regime or 'cure' which significantly improves my morphology i figure its best to share it with the world.

The doctor has given me some advice on improving my sperm morphology, and wants to see me again in 3 months for a retest. He said there are a few ray's of hope on my results; The motility (51%) and the volume (437 million) is quite good. Theres a chance a few of my guys are making it to the egg on a regular basis, they just cant crack it.

But If i can get the morphology up to just 1%, that equates to a whopping 4.37 million normal sperm, and our chances of successfully conceiving go up dramatically.

So that's my target, 1%.