Omega 3

Having moved on from researching anti-oxidants, I'm now looking at everything and anything else which could improve my sperm morphology, and honestly, its slim pickings.

The only thing i can find which isn't an antioxidant, is Omega 3.

There are a few studies out there which investigate the impact of Omega 3 on sperm morphology, this one is perhaps the most interesting, it essentially analysed Omega 3 intake for 99 men and compared various sperm parameters, it found;

"intake of omega-3 polyunsaturated fatty acids (PUFAs) was associated with higher normal sperm morphology. Men in the highest tertile of omega-3 fatty acid intake had a 2.2 (95% CI: 0.7 to 3.4) higher percentage of morphologically normal sperm than men in the lowest tertile of intake."

Here's the table with the stats, the higher the Omega 3 intake as a % of your diet, the higher the sperm morphology;

This is a minor improvement, but I'm looking for all the help i can get, so Omega 3 makes the (now completely full) supplement list!

Next up I'm going to look into acupuncture a little more as there appears to be a few studies out there which suggest it can have a positive impact on sperm morphology.

Pycnogenol - The last antioxidant

Pycnogenol is the last of the major antioxidants i think can help improve my Sperm morphology. It also appears to be one of the most powerful antioxidants available.

This paper, details some amazing improvements in sperm morphology - 19 people took 200mg of Pycnogenol a day for 3 months, and this was result;

"...Pycnogenol produced a 38% improvement in sperm morphology "

38% improvement!! That's huge!!

But there's more good news about Pycnogenol, this site concludes that when combined with COQ10, the power of both antioxidants is actually increased;

"The antioxidant effect of both micronutrients together was higher than expected from their respective individual activities, proving that CoQ10 and Pycnogenol cooperate synergistically for maintaining good cardiovascular health."

So Pycnogenol makes the list of antioxidant supplements.

Next up I'm going to look into other supplements which may improve morphology as my research into antioxidants has pretty much dried up!

What causes Teratozoospermia (Part 2)

The more I read up about Teratozoospermia (and not just Teratozoospermia, but male infertility in general), the more i am convinced that Oxidative Stress plays a huge role.

The building blocks behind healthy sperm are quite simple; maintain a healthy weight, exercise regularly (but not to excess), avoid stress and eat a healthy diet of protein, fruit and vegetables. This alone should give a man everything they need to create healthy sperm well into their 40's and 50's. Simple.

But for whatever reason, in some males, there appears to be something happening which impedes the healthy formation of sperm. For a healthy man to have 0% morphology at 33 years old is quite unusual, there must be something else at play, something which is constantly nuking the production process.... And almost every study out there seems to think its Oxidative stress.

There are a few things that (i think) I've come to understand over the last few months which could be impacting me;

1) Oxidative Stress on the testicles is something that can build up over time; The major culprits appear to be

• Alcohol 
• Poor diet
• Excessive heat (in fact i read in some cultures people use excessive heat to sterilise themselves!)

These things cause oxidative stress, which leads to poor sperm morphology.

But there's another source of Oxidative stress, and that's;

• Defective Sperm themselves - They essentially fall to pieces and in doing so, actually cause Oxidative Stress to the other healthy sperm.

So......

More Oxidative Stress means more Defective Sperm
More Defective Sperm leads to more Oxidative Stress

Its a vicious cycle which if left unchecked could totally trash the quality of your sperm.

This article provides a good overview of all things that can impact on sperm quality, it summarises;

"Spermatozoa are vulnerable to ROS (oxidative stress) because their plasma membrane and cytoplasm contain large amounts of polyunsaturated fatty acids.5 Excessive generation of ROS in semen by leukocytes as well as by abnormal spermatozoa could be a cause of infertility."

I think its possible my intake of antioxidants has been so low over the last few years that the build up of Oxidative Stress has pushed my sperm into this vicious cycle from which it cannot escape on its own..

2) Each cell in the body is under constant attack from Free radicals;

"Bruce Ames, a well-known scientist in the field of antioxidants, estimates that just one cell in the human body is hit about 10,000 times a day by a free radical. If that’s multiplied by the trillions of cells in the body the magnitude of this activity is tremendous."

10,000 times per day for each cell! That truly is huge, the one glass of orange juice a week i had on my old diet really wasn't enough to fight this barrage, so its no wonder my sperm production process has fallen into this vicious cycle. 

The 'cure' to all of this definitely appears to be a huge and ongoing dose of a variety of antioxidants, this should be enough to pull the sperm production process out of this funk and get things back on track. Time will tell, the next sperm test is only a few months away!

Vitamin C

Vitamin C (aka Ascorbic acid), i had no idea how important it was.

In my quest to understand the importance of Antioxidants in improving sperm morphology, I've stumbled across a few useful promising studies.

This study is particularly fascinating, 13 patients with low sperm counts (but normal morphology) were given a whopping 2000mg of vitamin C a day for 2 months, and this was the result;

A huge uptick across the board! Importantly for me though Morphology saw a huge increase, and it appears that the lower the starting morphology, the greater the improvement.

This study also suggested lower levels of vitamin C leads to higher rates of DNA damage within the sperm itself;

"When dietary AA was decreased from 250 to 5 mg/day, the seminal fluid AA decreased by half and the level of oxo8dG in sperm DNA increased 91%."

And this study further confirms that low levels of vitamin C appears to correlate with poor sperm morphology;

"Seminal AA in fertile and infertile (smokers or nonsmokers) males correlated significantly with the percentage of spermatozoa with normal morphology (p<0.01). Seminal AA decreased significantly in infertile men. Decrease of seminal plasma AA is a risk factor for low normal morphology of spermatozoa and idiopathic male infertility"

So I've immediately purchased some chewable vitamin C (500mg) tabs for my ever growing collection of supplements, I'm also going to add more citrus fruits to the diet... Aside from the odd glass of orange juice, this is something that admittedly has been almost totally absent for many, many years now.

CoQ10

I'm buying tome CoQ10.

While trawling the internet for more information on antioxidants, I found a useful summary which provided collection of studies on the effects of anti oxidants on sperm. Most interesting of this was this table, which provides an overview of all the studies, the anti-oxidants, and the results.

This study immediately caught my eye;

"RESULTS:

Mean sperm concentration, sperm progressive motility, and sperm with normal morphology improved significantly after 12-month CoQ(10) therapy by 113.7, 104.8, and 78.9%, respectively (all Ps < 0.05). The overall pregnancy rate was 34.1% within a mean of 8.4 ± 4.7 months.

CONCLUSIONS:

CoQ(10) supplementation improves semen quality with beneficial effect on pregnancy rate."

WOW! CoQ10 can improve sperm morphology by nearly 80%? 34% of participants had a spontaneous pregnancy during the study?! These are incredible figures!

This study was apparently a year long and involved 287 people taking 300mg of CoQ10 twice a day, so this isn't an overnight cure, but its a solid study and a promising start.

I've no idea if my poor sperm morphology is caused by oxidative stress or not, but even if its not, some CoQ10 apparently wont hurt my overall health, all of the CoQ10 studies appeared to have some sort of positive impact on sperm, with the higher doses having the greatest impact, so I'm heading over to Amazon now to do some shopping.

Lycopene (the tomato antioxidant)

I'm going to eat a lot more Tomatoes.

So, at the moment Antioxidants appears to be the way forward for improving Sperm morphology. And it turns out, there are loads of different types of Antioxidants.

In conducting my research I've come across another promising antioxidant called Lycopene. Lycopene is commonly found in tomatoes and other red vegetables. Something that my diet currently lacks.

There are a few promising articles about Lycopene and the effects on sperm (here, here, and here), the key headline appears to be 'New 'tomato pill' could SUPERCHARGE sperm by 70 per cent'

There is one old study here which suggests 4mg of Lycopene a day for 3 months had this result;

"Twenty patients (66%) showed an improvement in sperm concentration, sixteen (53%) had improved motility and fourteen (46%) showed improvement in sperm morphology."

There are clinical trials underway right now to prove whether 7mg can lead to further improvements, the supplement being tested has been developed by the university of Cambridge and can be found here.

While the previous studies appear promising, I'm reluctant to shell out cash for a somewhat unproven supplement, instead I've researched how many tomatoes I'll need to eat to get a daily dose of Lycopene.

This website suggests a simple tin of tomato soup will give me a whopping 13mg of Lycopene! so I'm going to adjust my diet accordingly to try and consume at least a tin of tomato soup a day.

UPDATE: This article reports on the effects a tin of tomato soup has on Lycopene levels in the testies (the antioxidant was detected but they didn't do any analysis into the impact on sperm).